Glipizide is an oral diabetic medication that aids in blood sugar management by stimulating insulin production in the pancreas. Glipizide is a medication used to treat high blood sugar in persons with type 2 diabetes. It may also be used in conjunction with other diabetic drugs. Controlling high blood sugar levels can help avoid kidney disease, blindness, nerve disorders, limb loss, and sexual function issues. Diabetes management may also reduce your risk of a heart attack or stroke. Glipizide is a sulfonylurea, which is a kind of medication. It reduces blood sugar by causing your body’s own insulin to be released.