Melphalan is a chemotherapy drug that is used to treat multiple myeloma and ovarian cancer. MelphalanIt belongs to the alkylating agent class of medicines. Melphalan is an anti-cancer medication. It operates by destroying the cancer cells’ genetic material (DNA and RNA). This stops their growth and multiplication of cancer cells. The most frequent Melphalan pill side effects include low blood cell counts, mouth sores, weariness, low potassium levels, and hair loss.